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  1. Unless stated otherwise specifically in the specification, the R of an acyloxy group is optionally substituted by one or more of the following substituents alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, oxo, thioxo, trimethylsilanyl, OR a, SR a, OC O R a, OC O OR a, OC O N R a 2, N R a 2, C O OR a, C O R a, C O N R a 2, N R a C O OR a, N R a C O N R a 2, N R a C NR a N R a 2, N R a C O R a, N R a S O t R a where t is 1 or 2, N R a S O t N R a 2 where t is 1 or 2, S O t R a where t is 1 or 2, S O t N R a 2 where t is 1 or 2, PO 3 R a 2, OPO 3 WY where W and Y are independently hydrogen, methyl, ethyl, alkyl, lithium, sodium or potassium or OPO 3 Z where Z is calcium, magnesium or iron, wherein each R a is independently hydrogen, alkyl, fluoroalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl misoprostol online trusted pharmacy Funk MB Lohmann A Guenay S et al

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